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4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.

Company Differentiators:

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine

GENERAL SUMMARY:

The Associate Scientist position in Biomarkers & Immunology will work with the lead Scientists for pathology sample processing, IHC/ISH assays, nucleic acid sample processing and ddPCR assays. The employee will be responsible for running experiments and sample processing to support method development and sample testing spanning vector characterization, non-clinical programs and to support clinical exploratory endpoints.

The Associate Scientist will be expected to work in a collaborative and flexible manner supporting other assays/workflows including biobank, safety and lab maintenance activities. In addition to hands on technical expertise, this position will be required to write up summaries/presentations of experimental data, maintain an up-to-date laboratory notebook and keep up with literature and scientific knowledge in the areas of gene therapy, histology techniques and bioanalytics.

KEY RESPONSIBLITIES

Hands on execution/interpretation/reporting of IHC/ISH experiments

Hands on method development/execution/interpretation/reporting of molecular biology (nucleic acid/ddPCR) experiments

Hands on cross training/scientific support for other assays/workflows such as cell culturing and biobank activities

Support Biomarker & Immunology department with sample processing and preparation

Effective data summary and presentation to internal teams

Histology imaging and sample archiving

Lab support includes maintaining inventory and supply ordering and sample tracking of FFPE blocks and glass slides including shipping and receiving samples.

QUALIFICATIONS:

Education & Experience:

BS or MS in related scientific discipline

2+ years industry experience

Skills:

Histology/IHC/ISH method development and troubleshooting

Histology sample processing

Experience in molecular biology: qPCR, ddPCR

Experience in accessioning/distribution of biosamples and maintaining biobank

Experience in testing large sample sets in an organized and efficient manner

Ability to adapt to changing priorities and requests

Excellent communication skills with internal 4D colleagues and external audiences

Excellent data summary/presentation skills

Additional requirements:

4-5 days/week onsite (as needed)

Adhere to PPE requirements and complete all required safety training

Adhere to 4DMT office and laboratory policies

Base salary compensation range: $118,000 - $136,000

Please note that salary will vary based on location, skill set, and a variety of other factors.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

4D Molecular Therapeutics jobs

Associate Scientist