Remix launched with a vision to transform patient’s lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to patients. Remix has a commitment to demonstrate the highest levels of scientific integrity with urgency because those patients are counting on us to deliver. With an in-house technology platform built from scratch, we have rapidly generated multiple drug discovery programs that are advancing towards the clinic.
Position Summary:
We seek a highly motivated, experienced biochemist/biophysicist to join our team located in Watertown, MA. The successful candidate will be an instrumental contributor within the Biomolecular Sciences and Lead Discovery (BSLD) department, helping drive various HTS campaigns using our existing suite of proprietary technologies while also enabling novel assays/modalities in our evolving platform.
This person will have a strong background in biochemistry and/or biophysics and will design and execute various in vitro assays at multiple stages of drug development (e.g., from high-throughput screening for early stage hit discovery through to lead optimization). The individual will have a track-record of success within a hypothesis-driven, team-oriented, and interdisciplinary laboratory setting. They will be expected to contribute to data generation, analysis, and visualization, as well as communicating with a cross-functional team of scientists in a thriving biotech environment.
Principal Duties and Responsibilities:
- Execute high-throughput screening campaigns with small molecule libraries
- Design and develop in vitro assays to screen/profile the binding and complex kinetics of small molecule compounds to large protein complexes
- Evaluate and implement novel biochemical and biophysical technologies for target and hit discovery
- Interpret, present, and report research findings in an open and timely manner
- Build and maintain productive relationships with colleagues in biomolecular sciences, biology, and chemistry
Qualifications:
- BS, M.Sc. or equivalent in biochemistry, biophysics, or a related discipline with 4-6+ years of experience working in a pharmaceutical/biotechnology laboratory setting
- Experience running multi-well plate-based in vitro assays with fluorescent/luminescent readouts (e.g. TR-FRET, FP) at various scales
- Experience working with laboratory automation, HTS, Hit-to-Lead, and compound management workflows is required
- Familiarity with various biochemical and biophysical techniques (including cutting-edge technologies e.g., SPR/GCI, MST, DSF, etc.) is desired
- Desire/ability to work in a multi-disciplinary team-focused environment
Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation, or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.
