Generation Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Delve further. Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/

SUMMARY:

Generation Bio is seeking a highly motivated, enthusiastic and detail-oriented scientist to join our rapidly growing Platform Imaging team. The primary responsibility of the candidate will be to support the development of novel imaging assays to further advance our non-viral gene therapy platform. The ideal candidate will have experience with cell-culture, transfection, and fluorescence-based molecular imaging techniques (e.g. immunofluorescence, ISH). The candidate is expected to work independently and efficiently with established assays and to support the development of new technologies working closely with experienced imaging scientists. This is a significant learning opportunity, and the candidate is expected to be organized, efficient, and someone who is looking to develop their own expertise in imaging technologies. Significant cross functional interactions are expected with key partnerships between Pharmacology, Toxicology, and other departments.

RESPONSIBILITIES:

Plans and executes experiments, analyzes data and interprets results
Records findings in ELN (Benchling) and summarizes results in written and oral presentations
Prepares and images samples using a variety of novel and standard approaches
Performs qualitative and quantitative image analyses
Maintains awareness of relevant scientific advances in molecular imaging and pathology and suggests new approaches where appropriate
Contribute to improvement in the laboratory operational processes and establish standard operating protocols

QUALIFICATIONS

Masters degree or a Bachelor’s with a minimum of 2 years related experience
Industry experience preferred
Previous experience maintaining, propagating, seeding, transfecting, and preserving mammalian cell lines is required
Experience with primary cell culture would be asset
Must be able to independently execute complex protocols with precision, consistency, and a mechanistic understanding of the steps
Experience with immunofluorescence, in situ hybridization, and/or other imaging preparations is highly desirable
Hands-on experience with fluorescence microscopy is a plus
Ability to support multiple projects across the platform
Ability to work in a highly collaborative, team-based environment
Organized, excellent communication skills, collaborative, team player mindset
Excellent written and verbal communication skills

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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